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Thread: Theoretical human proteome quantification profile!

  1. #1
    Angiotensin Member
    Join Date
    Nov 2011
    Tehran, Iran

    Theoretical human proteome quantification profile!

    Hi All

    I was wondering how can we make a theoretical human proteome quantify profile? Is it possible to do it? I mean there is a paper from Gygi SP (http://www.ncbi.nlm.nih.gov/pubmed?t...%202000%20PNAS) where they used Codon bias to evalute 2-DE. However, codon bias can not be used on human. There is emPAI (http://www.ncbi.nlm.nih.gov/pubmed?t...n%202005%20MCP) introduce by Mann. Here you need to have experiment data also. Is there software where we can give the human proteome database such as UniProtKB/Swiis-Prot and give us some index for abundancy of proteins? I am going to far ... I am not a programming guy, I am only interested in the programs which can do it ...

    Last edited by Kambiz; 04-24-2012 at 02:25 AM.

  2. #2
    Glycine Member
    Join Date
    Oct 2011
    Check out the GPM's human proteome guide. It's a report, not an algorithm, but it gives a great overview of observable proteins and the number of observations, which gives a rough guide to overall quantity.

  3. #3
    Albumin Member
    Join Date
    Sep 2011
    I dont know about whole proteome but ISB people have something on Estimated Concentrations on proteins in Human Plasma.

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